于艳艳

团队介绍

于艳艳,女,汉族,1988年9月生,副教授,博士

手机：15190948711

Email：yuyanyan@ntu.edu.cn

教育经历：

2010-09至2015-06，中山大学，伟德BEVICTOR，博士，导师：陈缵光教授

2006-09至2010-06，吉林大学，伟德BEVICTOR，学士

科研与学术工作经历：

(1) 2020-07至今，伟德BEVICTOR，伟德BEVICTOR，副教授

(2) 2015-09-2020-06，伟德BEVICTOR，伟德BEVICTOR，讲师

(3) 2018-11至2019-11，佐治亚理工学院，访问学者，合作导师：夏幼南教授

(4) 2016-11至2018-11，中国科学院上海应用物理研究所，博士后，合作导师：樊春海院士

于艳艳，伟德BEVICTOR(中国)有限公司副教授，硕士生导师，江苏省优青（2021年），从事DNA纳米技术及其生物医学应用的研究。在核酸检测，临床和生物样品分析，靶向纳米载体的构建和疾病治疗等领域取得了系列研究成果。迄今以第一作者/通讯作者在Anal. Chem., Biosens. Bioelectron., Chem. Commun.等SCI源期刊发表学术论文十余篇（影响因子大于10的4篇，大于5的14篇），其中2篇入选ESI高被引论文，2篇被选为封面报道（Chem. Commun., 2020, 56, 8599-8602，inside cover；Anal. Chem., 2021, 93, 4126–4133, front cover）。论文总被引800余次，H-index为14。

自2015年以来，主持国家级、省部级和市厅级项目共8项，具体如下：

1. 江苏省科技厅，优秀青年基金，BK20211604，基于CRISPR技术的免疫层析试纸法用于SARS-CoV-2双靶标联合检测，2021-07至2024-06，50万元，在研，主持

2. 南京大学“生命分析化学国家重点实验室” 开放基金，SKLACLS2013，变构响应型多信号三维DNA探针的构建及应用，2020-04至2022-03，5万元，在研，主持

3. 南通市科技局，社会民生面上，MS12021051，CRISPR多通道响应新技术的开发及用于SARS-CoV-2可视化现场检测，2021-07至2023-06，10万元，在研，主持

4. 南通市科技局，新型冠状病毒专项，XG202008-4，等温扩增式3D折纸芯片的研发及用于新型冠状病毒检测，2020-03至2022-02，4万元，在研，主持

5. 国家自然科学基金委员会，青年项目，21705082，纸基变构响应型三维传感界面的构建及其p53/MDM2相互作用抑制剂研究应用，2018-01至2020-12，25万元，已结题，主持

6. 江苏省科技厅，青年项目，BK20170444，3D折纸芯片传感系统的构建及用于p53/MDM2相互作用抑制剂的研究，2017-07至2020-06，20万元，已结题，主持

7. 中国博士后科学基金会，面上项目，2017M611640，集成式双信号响应型三维纳米探针的构建及传感应用，2017-01至2018-11，5万元，已结题，主持

8. 南通市科技局，科技计划项目，MS12016023，基于DNA等温指数扩增的生物传感器用于卵巢癌的早期联合诊断，2016-10至2018-09，3万元，已结题，主持

部分代表性第一作者和通讯作者论文

1. Wei S. Zhang^#，Jianbin Pan^#, Feng Li, Min Zhu, Mengting Xu, Hongyan Zhu, Yanyan Yu*, Gaoxing Su*, Reverse-Transcription Recombinase Polymerase Amplification Coupled CRISPR-Cas12a for Facile and Highly Sensitive Colorimetric SARS-CoV-2 Detection, Analytical Chemistry, 2021, 93 (8): 4126–41333，通讯，IF: 6.986

2. Yanyan Yu^#, Wei S. Zhang^#, Yuehua Guo, Huaping Peng, Min Zhu, Dandan Miao, Gaoxing Su*, Engineering of exosome-triggered enzyme-powered DNA motors for highly sensitive fluorescence detection of tumor-derived exosomes, Biosensors and Bioelectronics, 2020, 167: 112482，一作，IF：10.618

3. Yanyan Yu^#, Zhongnan Huang^#, Yao Zhou, Lihua Zhang, Ailin Liu, Wei Chen*, Jianhua Lin*, Huaping Peng*, Facile and highly sensitive photoelectrochemical biosensing platform based on hierarchical architectured polydopamine/tungsten oxide nanocomposite film, Biosensors and Bioelectronics, 2019, 126: 1-6，一作，IF：10.618

4. Gaoxing Su^#, Min Zhu^#, Mengting Xu, Jianbin Pan, Yao Zhou, Hongyu Zhou, Wei S. Zhang, Yanli Tong*, Yanyan Yu*, Fluorescence resonance energy transfer-based DNA framework assembled split G-quadruplex nanodevices for microRNA sensing, Chemical Communications, 2020, 56 (88): 13583-13586，通讯，IF: 6.222

5. Min Zhu, Yanyan Yu*, Junfeng Zhu, Yao Zhou, Gaoxing Su, Hongyan Zhu, Yong Chen, Mingkai Liu*, Single nucleotide variant discrimination by toehold exchange spherical nucleic acids modulated on hierarchical molybdenum disulfide acanthospheres, Chemical Communications, 2020, 56 (61): 8599-8602，通讯，IF: 6.222

6. Dandan Miao, Yanyan Yu*, Yong Chen, Yin Liu, Gaoxing Su*, Facile Construction of i-Motif DNA-Conjugated Gold Nanostars as Near-Infrared and pH Dual-Responsive Targeted Drug Delivery Systems for Combined Cancer Therapy, Molecular Pharmaceutics, 2020, 17 (4): 1127-1138，通讯，IF: 4.939

7. Yanyan Yu, Yao Zhou, Min Zhu, Gaoxing Su*, Haohua Deng, Wei Chen*, Huaping Peng*, Dynamic split G-quadruplex programmed reversible nanodevice, Chemical Communications, 2019, 55 (3): 389-392，一作，IF: 6.222

8. Yanyan Yu, Yao Zhou, Min Zhu, Mingkai Liu, Hongyan Zhu, Yong Chen, Gaoxing Su*, Wei Chen*, Huaping Peng*, Programming a split G-quadruplex in a DNA nanocage and its microRNA imaging in live cells, Chemical Communications, 2019, 55 (35): 5131-5134，一作，IF: 6.222

9. Yanyan Yu^#, Min Zhou^#, Wei Zhang, Lei Huang, Dandan Miao, Hongyan Zhu*, Gaoxing Su*, Rattle-Type Gold Nanorods/Porous-SiO2 Nanocomposites as Near-Infrared Light-Activated Drug Delivery Systems for Cancer Combined Chemo–Photothermal Therapy, Molecular Pharmaceutics, 2019, 16 (5): 1929-1938，一作，IF: 4.939

10. Yu Yanyan, Su Gaoxing, Zhu Hongyan, Zhu Qing, Chen Yong, Xu Bohui, LiYuqin, Zhang Wei*. Proximity hybridization-mediated isothermal exponentialamplification for ultrasensitive electrochemical protein detection,International Journal of Nanomedicine, 2017, 12: 5903-5914，一作，IF: 6.4

11. Yanyan Yu, Zuanguang Chen^*, Wensi Jian, Duanping Sun, Beibei Zhang, Xinchun Li, Meicun Yao^*, Ultrasensitive electrochemical detection of avian influenza A (H7N9) virus DNA based on isothermal exponential amplification coupled with hybridization chain reaction of DNAzyme nanowires, Biosensors and Bioelectronics, 2015, 64: 566-571，一作，IF: 10.618

12. Yanyan Yu, Zuanguang Chen^*, Lijuan Shi, Fan Yang, Jianbin Pan, Beibei Zhang, Duanping Sun, Ultrasensitive Electrochemical Detection of MicroRNA Based on an Arched Probe Mediated Isothermal Exponential Amplification, Analytical Chemistry, 2014, 86 (16): 8200-8205，一作，IF: 6.986

13. Yanyan Yu, Zuanguang Chen, Sijing He, Beibei Zhang, Xinchun Li, Meicun Yao^*, Direct electron transfer of glucose oxidase and biosensing for glucose based on PDDA-capped gold nanoparticle modified graphene/multi-walled carbon nanotubes electrode, Biosensors and Bioelectronics, 2014, 52: 147-152，一作，IF: 10.618

14. Yanyan Yu, Zuanguang Chen^*, Beibei Zhang, Xinchun Li, Jianbin Pan, Selective and sensitive determination of uric acid in the presence of ascorbic acid and dopamine by PDDA functionalized graphene/graphite composite electrode, Talanta, 2013, 112: 31-36，一作，IF: 6.051

15. 于艳艳; 朱敏; 周垚; 苏高星; 朱红艳; 一种荧光共振能量转移生物传感器及其应用,专利号：201810829706.7

16. 于艳艳; 朱敏; 苏高星; 一种DNA框架包裹的G-四链体结构及其制备方法与应用，申请号：202011071468.1

17. 于艳艳; 苏高星; 朱敏; 张伟; 一种SARS-CoV-2检测试剂盒及检测方法，申请号：202110032321.X

18. 于艳艳; 朱敏; 周垚; 苏高星; 朱红艳; 一种用于卵巢癌标志物检测的试剂盒，专利号：201821184894.4