朱清
团队介绍
朱清,男,汉,1978.08,副教授,博士,天然药物系副主任
研究方向：
神经药理学与药物代谢
基金项目：
国家自然科学基金面上项目，82071238，基于疼痛抑制行为探讨去甲青藤碱靶向α2-GABAA受体的镇痛效应，2021/01-2024/12，55万，在研，主持（PI）
江苏省自然科学基金面上项目，BK20181459，基于疼痛抑制行为的去甲青藤碱镇痛效应及与GABAA受体相关机制研究，2018/07-2021/06，10万，在研，PI
江苏省自然科学青年基金项目，BK20181459，益母草碱抗心肌缺血作用及药效物质基础的代谢组学研究，2013/07-2016/06，20万，结题，PI
国家自然科学基金面上项目，81971243，TAAR1-CaMKII-CREB信号通路调节尼古丁成瘾，2020/01-2023/12，55万，在研，Co-PI（协助主持）
国家自然科学基金面上项目，81373390，选择性咪唑啉I2受体配体的镇痛效应及滥用潜力研究，2014/01-2017/12，65万元，结题，Co-PI
朱清， 李俊旭， 苏漫， 李洁佳， 欧云淘，一种镇痛药物组合物，2021/03/19
中国，ZL201710671939.4 （授权专利）
朱清，卫蒨蒨，唐文婷，李俊旭，潘菲，邱男青，周致用，李洁佳， 氧化前胡素的新用途，2020/05/08，中国 ZL201810813028.5（授权专利）
朱清，李俊旭，卫蒨蒨，潘菲，邱男青，李洁佳，氧化前胡素在制备治疗术后疼痛药物中的应用，2020/04/28，中国 ZL201810751676.2 （授权专利）
朱清，李俊旭，孙越华，青藤碱在制备治疗慢性疼痛伴抑郁行为药物中的应用，2017/01/04，中国，ZL201410456667.2（授权专利）
李俊旭，朱清，欧云淘，苏漫，赵颖，去甲青藤碱在制备镇痛药物中的应用，2019/12/20 中国，ZL201610331233.9（授权专利）
李俊旭，朱清，毛丽娜，刘成鹏，孙越华，牡荆素在制备治疗术后疼痛中的应用，2017.11.07，中国，ZL201510642790.8（授权专利）
代表性论文：
Zhiyong Zhou, Nanqing Qiu, Yuntao Ou, QianqianWei, WentingTang,MingcongZheng, Yaluan Xing, Jie Jia Li, Yong Ling, Junxu Li* & Qing Zhu*. N Demethylsinomenine, an active metabolite of sinomenine, attenuates chronic neuropathic and infammatory pain in mice. Scientifc Reports, 2021, 11:9300. (Corresponding author)
Yuntao Ou, Man Su, Yong Ling, Qianqian Wei, Fei Pan, Jiejia Li, Jun-Xu Li*, Qing Zhu*. Anti-allodynic effects of N-demethylsinomenine, an active metabolite of sinomenine, in a mouse model of postoperative pain. Eur. J. Pharmacol. 2018, 823:105–109. DOI: 10.1016/j.ejphar.2018.01.044. (Corresponding author)
Yong Ling, Jing Guo, Qiuxing Yang, Peng Zhu, Jiefei Miao, Weijie Gao, Yanfu Peng, Jiaying Yang, Kun Xu, Biao Xiong, Gongqing Liu, Jinhua Tao, Lin Luo, Qing Zhu*, Yanan Zhang*. Development of novel β-carboline-based hydroxamate derivatives as HDAC inhibitors with antiproliferative and antimetastatic activities in human cancer cells. Eur J Med Chem. 2018, 144:398-409. (Corresponding author)
Qing Zhu, Yuehua Sun, Lina Mao, Chengpeng Liu, Bo Jiang, Wei Zhang & Jun-Xu Li. Antinociceptive effects of sinomenine in a rat model of postoperative pain，British Journal of Pharmacology, 2016, 173:1693-1702.
Qing Zhu, Li-Na Mao, Cheng-Peng Liu, Yue-Hua Sun, Bo Jiang, Wei Zhang & Jun-Xu Li. Antinociceptive effects of vitexin in a mouse model of postoperative pain. Scientific Reports, 2016, 6:19266.
Qing Zhu, Yuehua Sun, Jie Zhu, Tian Fang, Wei Zhang & Jun-Xu Li. Antinociceptive effects of sinomenine in a rat model of neuropathic pain. Scientific Reports, 2014, 4: 7270.
Qing Zhu, Yuehua Sun, Xiaodi Yun, Yuntao Ou, Wei Zhang & Jun-Xu Li. Antinociceptive effects of curcumin in a rat model of postoperative pain, Scientific Reports, 2014, 4:4932.
Qing Zhu, Jinlian Zhang, Ping Yang, Bo Tan, Xinhua Liu, Yuanting Zheng, Weimin Cai & Yizhun Zhu. Characterization of Metabolites of Leonurine (SCM-198) in Rats after Oral Administration by Liquid Chromatography/Tandem Mass Spectrometry and NMR Spectrometry, The Scientific World Journal, 2014, 2014:947946.
Qing Zhu, Weimin Cai, Xianyi Sha, Guo Ma, Yuanting Zheng, Xueru Shi & Yizhun Zhu. Quantification of leonurine, a novel potential cardiovascular agent, in rat plasma by liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic study in rats, Biomedical Chromatography, 2012, 26(4): 518-523.
Jie-Jia Li#, Qing Zhu# (Co-First Author), Ya-Peng Lu, Peng Zhao, Zhan-Bo Feng, Zhong-Ming Qian & Li Zhu. Ligustilide prevents cognitive impairment and attenuates neurotoxicity in D-galactose induced aging mice brain, Brain Research, 2015,1595:19-28.
Donggeng Wang#, Qing Zhu # (Co-First Author), Baohua Liu, Guangtong Chen & Yong Ling. Identification of gut microbial metabolites of a synthetic nitric oxide-releasing farnesylthiosalicylic acid derivative, an antitumor agent, Analytical Letters, 2014, 47(2):191-201.
Qing Zhu, Jinhua Gu, Hongyan Zhu & Jiliang Xu. Identification of differentially expressed genes in dorsal root ganglion in early diabetic rats, Neuroscience Bulletin, 2008, 24(4):219-24.